Question:
Actually with chronic depression that would make sense.
It would? Also with Dexedrine- there is a known rebound effect causing depression when used at very high dosages. The same effect exists for amphetamines in general, the "crash" that follows a speed binge.
Eesh, well, I’ve never taken more than 15mg at a time. Normally the dosages involved are at abuse levels but I don’t see any reason someone couldn’t be particularly sensitive to it at normal therapeutic levels.
I usually am overly sensitive to just about *any* medication. I didn’t notice this rebound effect with Dex until recently. I haven’t been this depressed before either. I don’t think. Yeah, I was more bent on killing myself, but I was much less depressed then. Weird. It’s not listed as a side effect but other cognitive effects such as euphoria are so who knows, it’s possible.
I’ve seen the PDR write-up on Dex and I think it does say something about mental depression if it is stopped suddenly. I stopeed it pretty suddenly, but that was months ago and I was much too stressed about the asthma attack to be depressed. It’s only recently that I’ve been taking 5mg or 10mg and I notice this rebound effect. Well, before the crash back in Feburary too I think I noticed some rebound from too, but I’m not sure since I was very very sick. I looked at Wellbutrin and Dexedrine at www.mentalhealth.com They don’t seem to be a problem together. Both interact negatively with MAO inhibitors ( what doesn’t ) and Wellbutrin reacts with phenobarbital. Your doctor will have a better idea of the interactions.
Maybe, but he goes by an ancient PDR. Ah well. I suppose I could use the one at the library. — http://jenwolf.virtualave.net/
Response:
(Jen Snippage) I’m wondering if they can’t prescribe an antidepressant along with the Dex because it sounds like you need something else for the depression itself. You might want to check with the doc. "If a person has a choice between guilt and shame, they’ll go for the guilt every time." — Ken Rivers
Response:
Jen said: "It’s when it wears off that things (consistently) become/feel worse. " Jen that’s really interesting (well, I find all of your insights interesting, and I bet all the rational people here do, but this one is particularly startling.) Why couldn’t there be an "emotional" rebound? The "regular" rebound is usually managed by adding a half dose as it’s wearing off. Have you tried that? Would your doctor "go" for it?
Response:
I usually am overly sensitive to just about *any* medication. I didn’t notice this rebound effect with Dex until recently. I haven’t been this depressed before either. I don’t think. Yeah, I was more bent on killing myself, but I was much less depressed then. Weird.
No, not thst weird. Lots of people , once they "decide" actually lighten up as it seems that everything will then fall into place. Of course, you know it doesn’t solve anything, but yout mood might well have improved. Jen, you’re so good at expressing these dark tunnels and valleys that many people feel and can’t articulate, even in their own heads. While it’s a struggle for anyone as sensitive as you are, still there must be something that can make it a little easier (and not a mini-wage McJob) Try a Medline search and then print out the stuff that’s newer than what your Dr. has at his feeble fingertips. Keep us posted. Kate Coe
Response:
Actually with chronic depression that would make sense. It would?
Yep. In any severe or chronic depression there is a component of anxiety. In some people it’s pronounced, in some it’s not, but it’s always there. It’s nothing like an anxiety attack but it’s what gives the depression it’s immediacy at times. You said that when you took Dexedrine you felt calmer. In some people Dexedrine can cause an anti-anxiety effect. It does in me, so do most of the amphetamines. So, when you stop the Dexedrine the anxiety returns and the depression seems more immediate and stronger than when you were on the Dexedrine. It’s hard to put it into words, you’re a lot better at that than I am, but *I* know what I mean….;-) Of course I could be completely wrong…… YMMV
Response:
What is the typical Wellbutrin dosage given for ADD? I’m using it for depression along with St. John’s wort (with Doctor’s supervision). I’m doing well with these for depression but haven’t found help for my ADD. JOhn Before you buy.
Response:
Dexedrine and depression.
Wat iz Dexdine? Do u need a subscription? Sumwon tell ma it hepp u focuis bedder? Iz dis tru? Poopie Pants – Hide quoted text — Show quoted text -Question: Can or does Dexedrine *cause* depression? Thoughts: I went for several weeks with no Dexedrine whatsoever, and still felt depressed. I do not feel so bad when the Dexedrine is in effect, is this because I am busy doing things or because the Dexedrine has changed something (neurotrasmitter levels or whatever)? On the other hand now that I think of it, sometimes when the Dex is in effect I feel worse or the same. Considering how I felt before ever taking Dex, that would be consistent with my normal state-of-being. However, Dex must have a rebound effect that isn’t as quick to happen as with Ritalin or Adderall because I definately feel worse almost every time it wears off. . .and it just sort of creeps up on me whereas with Ritalin and Adderall it happened very suddenly. Would an anti-depressant, such a Wellbutrin, fix that? I get *so* frustrated going without Dex because I can’t sit and read, can’t work on any programming or graphic designing or writing, can’t even finish washing the dishes. I just pace around aimlessly. Even as depressed as I supposedly am, I am still too hyperactive to even lie in bed all day (although I do keep going in there and trying). I have this problem with wanting things to be/get done *right now.* I’m unwilling or unable to slow down and take the inbetween steps. My usual dosage of Dex helped considerably with that. Now, every little set back is a major crisis to the point where doing any damned thing is a total waste of time. That’s depressing. Anyway, I’m worried that I will not be able to get back to the level of functioning I had. Yes, I still had problems and was depressed the whole time, but at least *some* things seemed worthwhile and I could get up and go to work/school every day and I had some plans/hope for improvement. Now that I think of it, I was really, really depressed last year and could not have gone on much longer even if I *hadn’t* had the asthma attack. That just made it all happen all at once, like an explosion. Or would it have got better with the right environment? I’ll never know. That’s why I wonder if Dexedrine can *cause* depression. There’s no doubt I was depressed before taking Dex, before taking Rit and anything else. Did Dex just make me more aware? Did Dex raise my level of functioning enough that I could see what a failure I’d been and how I was headed for even more? Sometimes ignorance really is bliss, imo. I’m still amazed at the amount I was able to learn and accomplish in the short time I was taking the drug. The whole ordeal reminds me of that story Flowers for Algernon. People who know me in real space are amazed at the change when I take Dex. I’m *much* calmer, considerably more rational, and much easier to get along with. But even with Dex and in the wrong environment I’m no better. And I’m always still depressed and never satisfied with my own accomplishments. Why? Now I just feel stuck. I know allergy shots take time to work, but I’m still stuck with all these asthma medicines. Will they interact negatively with Wellbutrin like they did with the Dexedrine? Should I take just the Wellbutrin and scrap Dex for now? Can they even be taken together? Maybe nothing will help. As it is, I have to wait a several more days to see my doctor. Several more days to change my mind. : — http://jenwolf.virtualave.net/
Visit my newsgroup alt.poopy-pants Askii Poopie for advice on just about anything. Some of it may actually be useful I’m mentally ill and I have a toilet plunger, any questions? Go to this link for a self-analysis http://www.laugh-your-ass-off.com/names.htm I love the smell of linseed oil. Poopie has now attained diety status, in the eyes of Rick_D from alt.support.attn-deficit anyway…. Here is an excerpt from one of his posts: Along comes Dr. Poopie Pants, himself who asked me Rick, Why U so inteerested in me? I guess the previous paragraph says why, and my gratitude for carrying that lesson home in a way I might not have is there. Really, if you look at what the good Dr says it is very insightful. Often in life I have a bias to those who do not present themselves in some way as socially acceptable. It shows me some form of art in practice and Dr. Poopie Pants, like Carlos Castenada’s Don Juan, Louis the 14th’s Voltaire, and Jesus Christ of Nazareth (a special story of faith) are of the same genre and quality.
Response:
"Wat iz Dexdine? Do u need a subscription? Sumwon tell ma it hepp u focuis bedder? Iz dis tru?" It’s a suppository. Want me to send you some?
Response:
"Wat iz Dexdine? Do u need a subscription? Sumwon tell ma it hepp u focuis bedder? Iz dis tru?" It’s a suppository. Want me to send you some?
Sure Susann Mrs Helperton Hears ma addreesss: Reverind Dr Poopie Pants 455 N. Galvin Parkway in Papago Park, Phoenix, Arizona 85008-3431 Phone: 602.273.1341 FAX: 602.273.7078 I incluyed ma fon numer an faxx incase ya wanna juss fax ma sum. Poopie Pants Visit my newsgroup alt.poopy-pants Askii Poopie for advice on just about anything. Some of it may actually be useful I’m mentally ill and I have a toilet plunger, any questions? Go to this link for a self-analysis http://www.laugh-your-ass-off.com/names.htm I love the smell of linseed oil. Poopie has now attained diety status, in the eyes of Rick_D from alt.support.attn-deficit anyway…. Here is an excerpt from one of his posts: Along comes Dr. Poopie Pants, himself who asked me Rick, Why U so inteerested in me? I guess the previous paragraph says why, and my gratitude for carrying that lesson home in a way I might not have is there. Really, if you look at what the good Dr says it is very insightful. Often in life I have a bias to those who do not present themselves in some way as socially acceptable. It shows me some form of art in practice and Dr. Poopie Pants, like Carlos Castenada’s Don Juan, Louis the 14th’s Voltaire, and Jesus Christ of Nazareth (a special story of faith) are of the same genre and quality.
Response:
I think the bottom line on psychotropic drugs is that the most effective drug and its dosage varies with the individual. A good doctor should know that and be willing to experiment. I take 150 mg of Wellbutrin SR when I wake up and then another 8 hours later. I haven’t seen many in the group who are taking just Wellbutrin for ADD. Please let me know how you are finding it. Regards, — Ian New to the group? www.cyber-mall.com/asad/ – Hide quoted text — Show quoted text – What is the typical Wellbutrin dosage given for ADD? I’m using it for depression along with St. John’s wort (with Doctor’s supervision). I’m doing well with these for depression but haven’t found help for my ADD. JOhn Before you buy.
Response:
Susan don’t forget to send him the hammer and chisel "easy applicator kit". — Ian New to the group? www.cyber-mall.com/asad/ – Hide quoted text — Show quoted text – "Wat iz Dexdine? Do u need a subscription? Sumwon tell ma it hepp u focuis bedder? Iz dis tru?" It’s a suppository. Want me to send you some?
Response:
FWIW, I’m told that some folks with ADHD become depressed after they go on meds not because of any direct effect of the meds but because they realize how much work they are going to have to do to get to where they want to be. — — — John Reply to jclarke at eye bee em dot net
– Hide quoted text — Show quoted text – I don’t think it *causes* depression unless abused… but it can aggravate depression, and it can make one more aware of depressed feelings, which of course are very painful. It’s a universal "alerter" — everything becomes more obvious, including emotional feelings. I dunno, I really think it’s more some sort of rebound effect and I was depressed before ever taking it and the depression just continued and got worse for other reasons. Thing is, on Dex my emotions are much smoother and calmer. It’s when it wears off that things (consistently) become/feel worse. And of course in the wrong sort of environment, like I was in last year, nothing helps me emotionally. I just don’t know for sure, though. I do know one thing for certain: I’ve never felt more "alert" with Dexedrine. I’ve definately felt more rational and mentally organized, but never more alert. In fact, there were many times when I felt *less* alert after taking Dex and simply fell asleep. — http://jenwolf.virtualave.net/
Response:
Why couldn’t there be an "emotional" rebound?
It’s odd because I did not experience it when I was taking considerably more Dex. The "regular" rebound is usually managed by adding a half dose as it’s wearing off. Have you tried that? Would your doctor "go" for it?
Yeah, it’s a good plan, but I’ve found that I can’t tolerate any more than 10mg perday because of side effects associated with these asthma medications. Come to think of it, maybe that’s what’s causing the effects of Dex to feel different. — http://jenwolf.virtualave.net/
Response:
Yep. In any severe or chronic depression there is a component of anxiety. In some people it’s pronounced, in some it’s not, but it’s always there. It’s nothing like an anxiety attack but it’s what gives the depression it’s immediacy at times. You said that when you took Dexedrine you felt calmer. In some people Dexedrine can cause an anti-anxiety effect. It does in me, so do most of the amphetamines.
I wouldn’t call it anxiety, but maybe I don’t know the definition of anxiety. I’m not anxious at all anyway. The feeling is like a severe pain that slowly spreads all over the inside until even my stomach hurts. So, when you stop the Dexedrine the anxiety returns and the depression seems more immediate and stronger than when you were on the Dexedrine.
I still wouldn’t call it anxiety, but yeah that’s about it. It’s hard to put it into words, you’re a lot better at that than I am, but *I* know what I mean….;-) Of course I could be completely wrong…… YMMV
Shrug. Maybe it’s something that came along with these asthma meds and Dex mixing. I’m just worried that I will never be able to take Dex again and lose everything I worked for. Right now I can’t stop the asthma meds, and I don’t know when I will be able to stop them or even cut them down. The last time I took allergy shots it took more than a year for them to really start working. Sigh. — http://jenwolf.virtualave.net/
Response:
Jen, you’re so good at expressing these dark tunnels and valleys that many people feel and can’t articulate, even in their own heads. While it’s a struggle for anyone as sensitive as you are, still there must be something that can make it a little easier (and not a mini-wage McJob) Try a Medline search and then print out the stuff that’s newer than what your Dr. has at his feeble fingertips. Keep us posted. Kate Coe
Thanks. — http://jenwolf.virtualave.net/
Response:
J Clarke said: "FWIW, I’m told that some folks with ADHD become depressed after they go on meds not because of any direct effect of the meds but because they realize how much work they are going to have to do to get to where they want to be." Another common issue down that road for adults is a sense of loss over what might have been had they gotten treatment earlier, not been "blessed" with this disorder, etc.
Response:
Jen said: " The "regular" rebound is usually managed by adding a half dose as it’s wearing off. Have you tried that? Would your doctor "go" for it?
Yeah, it’s a good plan, but I’ve found that I can’t tolerate any more than 10mg perday because of side effects associated with these asthma medications. Come to think of it, maybe that’s what’s causing the effects of Dex to feel different." Ohhh durn… that is a difficult combination. Well, all I can do is cross my fingers with you — and hope you continue to post. I bet all the rational people here enjoy your posts as much as I do.
Response:
- Hide quoted text — Show quoted text – Yep. In any severe or chronic depression there is a component of anxiety. In some people it’s pronounced, in some it’s not, but it’s always there. It’s nothing like an anxiety attack but it’s what gives the depression it’s immediacy at times. You said that when you took Dexedrine you felt calmer. In some people Dexedrine can cause an anti-anxiety effect. It does in me, so do most of the amphetamines. I wouldn’t call it anxiety, but maybe I don’t know the definition of anxiety. I’m not anxious at all anyway. The feeling is like a severe pain that slowly spreads all over the inside until even my stomach hurts.
The definition of anxiety- outside of acute anxiety attacks is: painful or apprehensive uneasiness of mind
That’s why I said it was hard to describe. The anxiety I mean doesn’t feel like panic. I think that despair would be a better comparison. Despair has a strong anxiety component to it, that’s why it feels immediate. Shrug. Maybe it’s something that came along with these asthma meds and Dex mixing. I’m just worried that I will never be able to take Dex again and lose everything I worked for. Right now I can’t stop the asthma meds, and I don’t know when I will be able to stop them or even cut them down. The last time I took allergy shots it took more than a year for them to really start working. Sigh.
I wouldn’t worry too much about the asthma meds until you talk to your doctor. It still sounds to me as if the Dexedrine is interacting with the depression. If you can do something with the depression the Dexedrine problem should take care of itself.
Response:
Yes, any stimulant can "cause" depression as one withdraws from it. Best not to use this med on a child with depressive mood disorder. By the way, stimulants were used as the first antidepressants at the turn of (last) century as they DO elevate the mood, but unfortuneately only for a short time and then bigger problems return.
– Hide quoted text — Show quoted text – Dexedrine and depression. Question: Can or does Dexedrine *cause* depression? Thoughts: I went for several weeks with no Dexedrine whatsoever, and still felt depressed. I do not feel so bad when the Dexedrine is in effect, is this because I am busy doing things or because the Dexedrine has changed something (neurotrasmitter levels or whatever)? On the other hand now that I think of it, sometimes when the Dex is in effect I feel worse or the same. Considering how I felt before ever taking Dex, that would be consistent with my normal state-of-being. However, Dex must have a rebound effect that isn’t as quick to happen as with Ritalin or Adderall because I definately feel worse almost every time it wears off. . .and it just sort of creeps up on me whereas with Ritalin and Adderall it happened very suddenly. Would an anti-depressant, such a Wellbutrin, fix that? I get *so* frustrated going without Dex because I can’t sit and read, can’t work on any programming or graphic designing or writing, can’t even finish washing the dishes. I just pace around aimlessly. Even as depressed as I supposedly am, I am still too hyperactive to even lie in bed all day (although I do keep going in there and trying). I have this problem with wanting things to be/get done *right now.* I’m unwilling or unable to slow down and take the inbetween steps. My usual dosage of Dex helped considerably with that. Now, every little set back is a major crisis to the point where doing any damned thing is a total waste of time. That’s depressing. Anyway, I’m worried that I will not be able to get back to the level of functioning I had. Yes, I still had problems and was depressed the whole time, but at least *some* things seemed worthwhile and I could get up and go to work/school every day and I had some plans/hope for improvement. Now that I think of it, I was really, really depressed last year and could not have gone on much longer even if I *hadn’t* had the asthma attack. That just made it all happen all at once, like an explosion. Or would it have got better with the right environment? I’ll never know. That’s why I wonder if Dexedrine can *cause* depression. There’s no doubt I was depressed before taking Dex, before taking Rit and anything else. Did Dex just make me more aware? Did Dex raise my level of functioning enough that I could see what a failure I’d been and how I was headed for even more? Sometimes ignorance really is bliss, imo. I’m still amazed at the amount I was able to learn and accomplish in the short time I was taking the drug. The whole ordeal reminds me of that story Flowers for Algernon. People who know me in real space are amazed at the change when I take Dex. I’m *much* calmer, considerably more rational, and much easier to get along with. But even with Dex and in the wrong environment I’m no better. And I’m always still depressed and never satisfied with my own accomplishments. Why? Now I just feel stuck. I know allergy shots take time to work, but I’m still stuck with all these asthma medicines. Will they interact negatively with Wellbutrin like they did with the Dexedrine? Should I take just the Wellbutrin and scrap Dex for now? Can they even be taken together? Maybe nothing will help. As it is, I have to wait a several more days to see my doctor. Several more days to change my mind. : — http://jenwolf.virtualave.net/
Response:
"Chalon" said "Yes, any stimulant can "cause" depression as one withdraws from it. Best not to use this med on a child with depressive mood disorder." While anti-depressants can sometimes aggravate depression, just as often in the person with ADHD they help relieve it, because the depression stems at least partly from the struggles with the ADHD. I don’t agree with this person’s advice. I think if a person has both ADHD and depression, treating only one is like having two broken legs, putting one in a cast and ignoring the other, and calling it an improvement. We don’t have to agree of course. That’s my take on it. Disclaimer: if anyone is offended by my post please make sure you’re not reading in between the lines and reacting to something I didn’t actually say first. Thanks.
Response:
It depends on how depressed the person is. Naturally depression can be life-threatening more often than ADD. On that basis treatment of depression could be more emergent, while ADD is a chronic condition. I am assuming that the depression is "caused" or significantly exacerbates the depression – again if the depression is major, it may be best to stop the stimulant, at least until the depression is managed.
– Hide quoted text — Show quoted text – "Chalon" said "Yes, any stimulant can "cause" depression as one withdraws from it. Best not to use this med on a child with depressive mood disorder." While anti-depressants can sometimes aggravate depression, just as often in the person with ADHD they help relieve it, because the depression stems at least partly from the struggles with the ADHD. I don’t agree with this person’s advice. I think if a person has both ADHD and depression, treating only one is like having two broken legs, putting one in a cast and ignoring the other, and calling it an improvement. We don’t have to agree of course. That’s my take on it. Disclaimer: if anyone is offended by my post please make sure you’re not reading in between the lines and reacting to something I didn’t actually say first. Thanks.
Response:
Dexedrine and depression. Question: Can or does Dexedrine *cause* depression? Thoughts: I went for several weeks with no Dexedrine whatsoever, and still felt depressed. I do not feel so bad when the Dexedrine is in effect, is this because I am busy doing things or because the Dexedrine has changed something (neurotrasmitter levels or whatever)? On the other hand now that I think of it, sometimes when the Dex is in effect I feel worse or the same. Considering how I felt before ever taking Dex, that would be consistent with my normal state-of-being. However, Dex must have a rebound effect that isn’t as quick to happen as with Ritalin or Adderall because I definately feel worse almost every time it wears off. . .and it just sort of creeps up on me whereas with Ritalin and Adderall it happened very suddenly. Would an anti-depressant, such a Wellbutrin, fix that? I get *so* frustrated going without Dex because I can’t sit and read, can’t work on any programming or graphic designing or writing, can’t even finish washing the dishes. I just pace around aimlessly. Even as depressed as I supposedly am, I am still too hyperactive to even lie in bed all day (although I do keep going in there and trying). I have this problem with wanting things to be/get done *right now.* I’m unwilling or unable to slow down and take the inbetween steps. My usual dosage of Dex helped considerably with that. Now, every little set back is a major crisis to the point where doing any damned thing is a total waste of time. That’s depressing. Anyway, I’m worried that I will not be able to get back to the level of functioning I had. Yes, I still had problems and was depressed the whole time, but at least *some* things seemed worthwhile and I could get up and go to work/school every day and I had some plans/hope for improvement. Now that I think of it, I was really, really depressed last year and could not have gone on much longer even if I *hadn’t* had the asthma attack. That just made it all happen all at once, like an explosion. Or would it have got better with the right environment? I’ll never know. That’s why I wonder if Dexedrine can *cause* depression. There’s no doubt I was depressed before taking Dex, before taking Rit and anything else. Did Dex just make me more aware? Did Dex raise my level of functioning enough that I could see what a failure I’d been and how I was headed for even more? Sometimes ignorance really is bliss, imo. I’m still amazed at the amount I was able to learn and accomplish in the short time I was taking the drug. The whole ordeal reminds me of that story Flowers for Algernon. People who know me in real space are amazed at the change when I take Dex. I’m *much* calmer, considerably more rational, and much easier to get along with. But even with Dex and in the wrong environment I’m no better. And I’m always still depressed and never satisfied with my own accomplishments. Why? Now I just feel stuck. I know allergy shots take time to work, but I’m still stuck with all these asthma medicines. Will they interact negatively with Wellbutrin like they did with the Dexedrine? Should I take just the Wellbutrin and scrap Dex for now? Can they even be taken together? Maybe nothing will help. As it is, I have to wait a several more days to see my doctor. Several more days to change my mind. : — http://jenwolf.virtualave.net/
Response:
"Dexedrine and depression. Question: Can or does Dexedrine *cause* depression?" I don’t think it *causes* depression unless abused… but it can aggravate depression, and it can make one more aware of depressed feelings, which of course are very painful. It’s a universal "alerter" — everything becomes more obvious, including emotional feelings.
Response:
I don’t think it *causes* depression unless abused… but it can aggravate depression, and it can make one more aware of depressed feelings, which of course are very painful. It’s a universal "alerter" — everything becomes more obvious, including emotional feelings.
I dunno, I really think it’s more some sort of rebound effect and I was depressed before ever taking it and the depression just continued and got worse for other reasons. Thing is, on Dex my emotions are much smoother and calmer. It’s when it wears off that things (consistently) become/feel worse. And of course in the wrong sort of environment, like I was in last year, nothing helps me emotionally. I just don’t know for sure, though. I do know one thing for certain: I’ve never felt more "alert" with Dexedrine. I’ve definately felt more rational and mentally organized, but never more alert. In fact, there were many times when I felt *less* alert after taking Dex and simply fell asleep. — http://jenwolf.virtualave.net/
Response:
I dunno, I really think it’s more some sort of rebound effect and I was depressed before ever taking it and the depression just continued and got worse for other reasons. Thing is, on Dex my emotions are much smoother and calmer. It’s when it wears off that things (consistently) become/feel worse. And of course in the wrong sort of environment, like I was in last year, nothing helps me emotionally. I just don’t know for sure, though.
Actually with chronic depression that would make sense. Also with Dexedrine- there is a known rebound effect causing depression when used at very high dosages. The same effect exists for amphetamines in general, the "crash" that follows a speed binge. Normally the dosages involved are at abuse levels but I don’t see any reason someone couldn’t be particularly sensitive to it at normal therapeutic levels. It’s not listed as a side effect but other cognitive effects such as euphoria are so who knows, it’s possible. I do know one thing for certain: I’ve never felt more "alert" with Dexedrine. I’ve definately felt more rational and mentally organized, but never more alert. In fact, there were many times when I felt *less* alert after taking Dex and simply fell asleep.
I looked at Wellbutrin and Dexedrine at www.mentalhealth.com They don’t seem to be a problem together. Both interact negatively with MAO inhibitors ( what doesn’t ) and Wellbutrin reacts with phenobarbital. Your doctor will have a better idea of the interactions.
Response: